Superfund Publications

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PubMed Central ID: 

Sherman M.H., Yu R.T., Tseng T.W., Sousa C.M., Liu S., Truitt M.L., He N., Ding N., Liddle C., Atkins A.R., Lebland M., Collisson E.A., Asara J.M., Kimmelman A.C., Downes M., Evans R.M. (2017) Stromal cues regulate the pancreatic cancer epigenome and metabolome.  Proc Natl Acad Sci U S A. 114: 1129-1134. doi: 10.1073/pnas.1620164114.

PubMedID: 28096419
PubMed Central ID: 

Park C.C., Nguyen P., Hernandez C., Bettencourt R., Ramirez K., Fortney L., Hooker J., Sy E., Savides M.T., Alquiraish M.H., Valasek M.A., Rizo E., Richards L., Brenner D., Sirlin C.B., Loomba R. (2017) Magnetic Resonance Elastography vs Transient Elastography in Detection of Fibrosis and Noninvasive Measurement of Steatosis in Patients With Biopsy-Proven Nonalcoholic Fatty Liver Disease. Gastroenterology. 152:598-607. doi: 10.1053/j.gastro.2016.10.026.

PubMedID: 27911262
PubMed Central ID: 

Clevers H., Karin M. (2016) Reparative Inflammation Takes Charge of Tissue Regeneration. Nature. 529: 307-15. doi: 10.1038/nature17039.

PubMedID: 26791721
PubMed Central ID: 

Chung H.K., Ryu D., Kim K.S., Chang J.Y., Kim Y.K., Yi H.-S., Kang S.G., Choi M.J., Lee S.E., Jung S.B., Ryu M.J., Kim S.J., Kweon G.R., Kim H., Hwang J.H., Lee C.-H., Lee S.-J., Wall C.E., Downes M., Evans R.M., Auwerx J., Shong M. (2017) Growth differentiation factor 15 (GDF15) is a myomitokine governing systemic energy homeostasis. J Cell Biol. 216: 149-165. doi: 10.1083/jcb.201607110.

PubMedID: 27986797
PubMed Central ID: 

Koyama Y., Brenner D.A. (2017) Liver inflammation and fibrosis. J Clin Invest. 127:55-64. doi: 10.1172/JCI88881.

PubMedID: 28045404
PubMed Central ID: 

Zhang Z., Xie Q., Jobe T.O., Kau A.R., Wang C., Li Y., Qiu B., Wang Q., Mendoza-Cózatl D.G., Schroeder J.I. (2016) Identification of AtOPT4 as a plant glutathione transporter. Mol Plant. 9: 481-4. doi: 10.1016/j.molp.2015.07.013.

PubMedID: 26283048
PubMed Central ID: 

Schoeller E.L., Clark D.D., Dey S., Cao N.V., Semaan S.J., Chao L.W., Kauffman A.S., Stowers L., Mellon P.L. (2016) Bmal1 Is Required for Normal Reproductive Behaviors in Male Mice. Endocrinology. 157:4914-4929. doi: 10.1210/en.2016-1620

PubMedID: 27704948
PubMed Central ID: 

Moscat, J., Karin, M., Diaz-Meco, M.T. (2016) p62 in Cancer: Signaling Adaptor Beyond Autophagy. Cell. 167:606-609. doi:10.1016/j.cell.2016.09.030.

PubMedID: 27768885
PubMed Central ID: 

Duran, A., Hernandez, E.H, Reina-Campos, M, Castilla, E.A., Subramaniam, S., Raghunandan, S., Roberts, L.R., Kisseleva, T., Karin, M., Diaz-Meco, M.T., Moscat, J. (2016) p62/SQSTM1 by binding to vitamin D receptor inhibits hepatic stellate cell activity, fibrosis and liver cancer. Cancer Cell. 30:595-609. doi: 10.1016/j.ccell.2016.09.004

PubMedID: 27728806
PubMed Central ID: 

Guo, L., Ganguly, A., Sun, L., Suo, F., Du, L.L., Russell. P. (2016) Global fitness profiling identifies arsenic and cadmium tolerance mechanisms in fission yeast. G3 (Bethesda). 6:3317-3333. doi: 10.1534/g3.116.033829.

 

PubMedID: 27558664
PubMed Central ID: 

Seki E. (2016) Acrolein, a New Villain in the Development of Alcoholic Liver Disease. Editorial.Cell Mol Gastroenterol Hepatol. 2:544-545. doi: 10.1016/j.jcmgh.2016.06.005

PubMedID: 28174735
PubMed Central ID: 

Liu M., Chen S., Yueh M.F., Fujiwara R., Konopnicki C., Hao H., Tukey R.H. (2016) Cadmium and arsenic override NF-κB developmental regulation of the intestinal UGT1A1 gene and control of hyperbilirubinemia. Biochem Pharmacol. 110-111:37-46. doi:10.1016/j.bcp.2016.04.003.

PubMedID: 27060662
PubMed Central ID: 

Hirashima R., Michimae H., Takemoto H., Sasaki A., Kobayashi Y., Itoh T., Tukey R.H., Fujiwara R. (2016) Induction of the UDP-Glucuronosyltransferase 1A1 during the Perinatal Period Can Cause Neurodevelopmental Toxicity. Mol Pharmacol. 90:265-74. doi: 10.1124/mol.116.104174.

PubMedID: 27413119
PubMed Central ID: 

Taniguchi, K., Yamachika, S., He, F., Karin, M. (2016) p62/SQSTM1- Dr. Jekyll and Mr. Hyde that prevents oxidative stress but promotes liver cancer. FEBS Lett. 590:2375-97.doi: 10.1002/1873-3468.12301

PubMedID: 27404485
PubMed Central ID: 

Koyama Y., Xu J., Liu X., Brenner D.A. (2016) New Developments on the Treatment of Liver Fibrosis. Dig Dis. 34:589-96. doi: 10.1159/000445269.

PubMedID: 27332862
PubMed Central ID: 

Wall C.E., Yu R.T., Atkins A.R., Downes M., Evans R.M. (2016) Nuclear receptors and AMPK: can exercise mimetics cure diabetes?J Mol Endocrinol. 2016 Apr 22. pii: JME-16-0073. doi: 10.1530/JME-16-0073.

PubMedID: 27106806
PubMed Central ID: 

Aleman F., Yazaki J., Lee M., Takahashi Y., Kim A.Y., Li Z., Kinoshita T., Ecker J.R., Schroeder J.I. (2016) An ABA-increased interaction of the PYL6 ABA receptor with MYC2 Transcription Factor: A putative link of ABA and JA signaling. Sci Rep. 6:28941. doi: 10.1038/srep28941.

PubMedID: 27357749
PubMed Central ID: 

Hsin I.-F., Montano E., Seki E. (2016) Finding a New Role for NEMO: A Key Player in Preventing Hepatocyte Apoptosis and Liver Tumorigenesis by Inhibiting RIPK1. Hepatology Elsewhere. Hepatology. 64:295-7. doi: 10.1002/hep.28627.

PubMedID: 27122117
PubMed Central ID: 

Umemura, A., He, F., Nakagawa, H., Yamachika, S., Taniguchi, K., Font-Burgada, J., Zhong, Z., Subramaniam, S., Raghunandan, S., Duran, A., Linares, J.F., Reina-Campos, M., Valasek, M.A., Seki,E., Yamaguchi, K., Koike, K., Itoh, Y., Diaz-Meco, M.T., Moscat, J., Karin, M. (2016) p62, upregulated during preneoplasia, induces hepatocellular carcinogenesis by maintaining survival of stressed HCC-initiating cells. Cancer Cell. 29:935-48. doi: 10.1016/j.ccell.2016.04.006.

PubMedID: 27211490
PubMed Central ID: 

Matsushita H., Yang Y.M., Pandol S.J., Seki E. (2016) Exosome Migration Inhibitory Factor as a Marker and Therapeutic Target for Pancreatic Cancer. Selected Summaries. Gastroenterology. 150:1033-5. doi: 10.1053/j.gastro.2016.02.051.

PubMedID: 26922869
PubMed Central ID: 

Lee, J.H., Cho, U.S., Karin, M. (2016) Sestrin regulation of TORC1: Is Sestrin a leucine sensor? Sci Signal. 9:re5. doi: 10.1126/scisignal.aaf2885

PubMedID: 27273098
PubMed Central ID: 

Booth D., Ding N., Parnell G., Shahijanian F., Coulter S., Schibeci S., Atkins A., Stewart G., Evans R.M., Downes M., Liddle C. (2016) Cistromic and genetic Evidence that the Vitamin D Receptor mediates Susceptibility to latitude-dependent Autoimmune Diseases.17:213-9. doi: 10.1038/gene.2016.12.

PubMedID: 26986782
PubMed Central ID: 

Karin, M., Dhar, D. (2016) Liver Carcinogenesis: From Naughty Chemicals to Soothing Fat- and the Suprising Role of NRF2. Carcinogenesis. 37:541-6. doi: 10.1093/carcin/bgw060

PubMedID: 27207669
PubMed Central ID: 

Yoshihara E., Wei Z., Lin C.S., Fang S., Ahmadian M., Kida Y., Tseng T., Dai Y., Yu R.T., Liddle C., Atkins A.R., Downes M., Evans R.M. (2016)  ERRγ Is Required for the Metabolic Maturation of Therapeutically Functional Glucose-Responsive β Cells.Cell Metab. 23:622-34. doi: 10.1016/j.cmet.2016.03.005.

PubMedID: 27076077
PubMed Central ID: 

Hoffmann, H. M., Trang, C., Gong, P., Kimura, I., Pandolfi, E. C., and Mellon, P. L. (2016) Deletion of Vax1 from GnRH Neurons Abolishes GnRH Expression and Leads to Hypogonadism and Infertility. Journal of Neuroscience. 36: 3506-3518. doi: 10.1523/JNEUROSCI.2723-15.2016.

PubMedID: 27013679
PubMed Central ID: 

Wang, C., Hu, H., Qin, X., Zeise, B., Xu, D., Rappel, W.-J., Boron, W.F., Schroeder, J.I. (2016) Reconstitution of CO2 regulation of SLAC1 anion channel and function of CO2-permeable PIP2;1 aquaporin as CARBONIC ANHYDRASE 4 interactor. Plant Cell. 282: 568-82. doi: 10.1105/tpc.15.00637.

PubMedID: 26764375
PubMed Central ID: 

Yamamoto Y., Negi J., Wang C., Isogai Y., Schroeder J.I., Iba K. (2016) The Transmembrane Region of Guard Cell SLAC1 Channels Perceives CO2 Signals via an ABA-Independent Pathway in Arabidopsis. Plant Cell. 28:557-67. doi: 10.1105/tpc.15.00583.

PubMedID: 26764376
PubMed Central ID: 

Yueh M.F., Tukey R.H. (2016) Triclosan: A widespread environmental toxicant with many biological effects. Annu Rev Pharmacol Toxicol. 56: 251-72. doi: 10.1146/annurev-pharmtox-010715-103417

PubMedID: 26738475
PubMed Central ID: 

Zhong, Z., Umemura, A., Sanchez-Lopez, E., Liang, S., Shalapour, S., Wong, J., He, F., Boassa, D., Perkins, G., Ali, S. R., McGeough, M. D., Ellisman, M. H., Seki, E., Gustafsson, A. B., Hoffman, H. M., Diaz-Meco, M. T., Moscat, J., Karin, M. (2016) NF-κB Restricts Inflammasome Activation via Elimination of Damaged Mitochondria. Cell. 2016 Feb 25;164(5):896-910. doi: 10.1016/j.cell.2015.12.057

PubMedID: 26919428
PubMed Central ID: 

Wang P., Koyama Y., Liu X., Xu J., Ma H.Y., Liang S., Kim I.H., Brenner D.A., Kisseleva T. (2016) Promising Therapy Candidates for Liver Fibrosis. Front Physiol. 7:47. doi: 10.3389/fphys.2016.00047.

PubMedID: 26909046
PubMed Central ID: 

Liu M., Chen S., Yueh M.F., Want G., Hao H., Tukey R.H. (2016) Reduction of p53 by knockout of the UGT1 locus in colon epithelial cells causes an increase in tumorigenesis. Cellular and Molecular Gastro and Hepatology. 2:63-76. doi: 10.1016/j.jcmgh.2015.08.008.

 

PubMedID: 26807433
PubMed Central ID: 

Suzuki, K., Yamaji, N., Costa, A., Okuma, E., Kobayashi, N. I., Kashiwagi, T., Katsuhara, M., Wang, C., Tanoi, K., Murata, Y., Schroeder, J. I., Ma, J. F., Horie, T. (2016) OsHKT1;4-mediated Na(+) transport in stems contributes to Na(+) exclusion from leaf blades of rice at the reproductive growth stage upon salt stress. BMC Plant Biol. 16(1), 22. doi: 10.1186/s12870-016-0709-4.

PubMedID: 26786707
PubMed Central ID: 

Ding N., Hah N., Yu RT., Sherman M.H., Benner C., Leblanc M., He M., Liddle C., Downes M., and Evans RM. (2015) BRD4 is a novel therapeutic target for liver fibrosis. Proc Nat Sci USA. 112: 15713-8.

PubMedID: 26644586
PubMed Central ID: 

Ding N., Hah N., Yu RT., Sherman M.H., Benner C., Leblanc M., He M., Liddle C., Downes M., and Evans RM. (2015) BRD4 is a novel therapeutic target for liver fibrosis. Proc Nat Sci USA. 112: 15713-8.

PubMedID: 26644586
PubMed Central ID: 

Yang, Y. M., Seki, E. (2015) TNFα in liver fibrosis. Curr Pathobiol Rep. 3(4), 253-261.

PubMedID: 26726307
PubMed Central ID: 

Basal autophagy maintains pancreatic acinar cell homeostasis and protein synthesis and prevents ER stress. (2015) Antonucci, L., Fagman, J. B., Kim, J. Y., Todoric, J., Gukovsky, I., Mackey, M., Ellisman, M. H., Karin, M. Proc Natl Acad Sci U S A. 112(45), E6166-74.

PubMedID: 26512112
PubMed Central ID: 

Finkin, S., Yuan, D., Stein, I., Taniguchi, K., Weber, A., Unger, K., Browning, J. L., Goossens, N., Nakagawa, S., Gunasekaran, G., Schwartz, M. E., Kobayashi, M., Kumada, H., Berger, M., Pappo, O., Rajewsky, K., Hoshida, Y., Karin, M., Heikenwalder, M., Ben-Neriah, Y., Pikarsky, E. (2015) Ectopic lymphoid structures function as microniches for tumor progenitor cells in hepatocellular carcinoma. Nat Immunol. 16(12), 1235-44.

PubMedID: 26502405
PubMed Central ID: 

Skowronska-Krawczyk, D., Zhao, L., Zhu, J., Weinreb, R. N., Cao, G., Luo, J., Flagg, K., Patel, S., Wen, C., Krupa, M., Luo, H., Ouyang, H., Lin, D., Wang, W., Li, G., Xu, Y., Li, O., Chung, C., Yeh, E., Jafari, M., Ai, M., Zhong, Z., Shi, W., Zheng, L., Krawczyk, M., Chen, D., Shi, C., Zin, C., Zhu, J., Mellon, P. L., Gao, W., Abagyan, R., Zhang, L., Sun, X., Zhong, S., Zhuo, Y., Rosenfeld, M. G., Liu, Y., Zhang, K. (2015) P16INK4a Upregulation Mediated by SIX6 Defines Retinal Ganglion Cell Pathogenesis in Glaucoma. Cell Mol. 59(6), 931-40. doi: 10.1016/j.molcel.2015.07.027.

PubMedID: 26365380
PubMed Central ID: 

Liu, Y., Trogler, W. C. (2015) Comment on 'Fluorescence sensing of arsenate at nanomolar level in a greener way: naphthalene based probe for living cell imaging. Chem Commun (Camb). 51(79),14775-7.

PubMedID: 26299989
PubMed Central ID: 

Brenner, D. A., Paik, Y. H., Schnabl, B. (2015) Role of Gut Microbiota in Liver Disease. J Clin Gastroenterol. 49 Suppl 1:S25-7.

PubMedID: 26447960
PubMed Central ID: 

Landrigan, P. J., Wright, R. O., Cordero, J. F., Eaton, D. L., Goldstein, B. D., Hennig, B., Maier, R. M., Ozonoff, D. M., Smith, M. T., Tukey, R. H. (2015) The NIEHS Superfund Research Program: 25 Years of Translational Research for Public Health. Environ Health Perspect. 123(10), 909-18. doi: 10.1289/ehp.1409247.

PubMedID: 25978799
PubMed Central ID: 

Mejia-Ramirez, E., Limbo, O., Langerak, P., Russell, P. (2015) Critical Function of γH2A in S-Phase. PLoS Genet. 11(9), e1005517.

PubMedID: 26368543
PubMed Central ID: 

Font-Burgada, J., Shalapour, S., Ramaswamy, S., Hsueh, B., Rossell, D., Umemura, A., Taniguchi, K., Nakagawa, H., Valasek, M. A., Ye, L, Kopp, J. L., Sander, M., Carter, H., Deisseroth, K., Verma, I. M., Karin, M. (2015) Hybrid Periportal Hepatocytes Regenerate the Injured Liver without Giving Rise to Cancer. Cell. 162(4), 766-79.

PubMedID: 26276631
PubMed Central ID: 

Ranjit, S., Dvornikov, A., Stakic, M., Hong, S. H., Levi, M., Evans, R. M., Gratton, E. (2015) Imaging Fibrosis and Separating Collagens using Second Harmonic Generation and Phasor Approach to Fluorescence Lifetime Imaging. Sci Rep. 5, 13378.

PubMedID: 26293987
PubMed Central ID: 

Brandt, B., Munemasa, S., Wang, C., Nguyen, D., Yong, T., Yang, P. G., Poretsky, E., Belknap, T. F., Waadt, R., Alemán, F., Schroeder, J. I. (2015) Calcium specificity signaling mechanisms in abscisic acid signal transduction in Arabidopsis guard cells. Elife.doi: 10.7554/eLife.03599

PubMedID: 26192964
PubMed Central ID: 

Xie, H., Hoffmann, H. M., Meadows, J. D., Mayo, S. L., Trang, C., Leming, S. S., Maruggi, C., Davis, S. W., Larder, R., Mellon, P. L. (2015) Homeodomain Proteins SIX3 and SIX6 Regulate Gonadotrope-specific Genes During Pituitary Development. Mol Endocrinol. 29(6), 842-55.

PubMedID: 25915183
PubMed Central ID: 

Engineer, C. B., Ghassemian, M., Anderson, J. C., Peck, S. C., Hu, H., Schroeder, J. I. (2014) Carbonic anhydrases, EPF2 and a novel protease mediate CO2 control of stomatal development. Nature. 513(7517), 246-50.

PubMedID: 25043023
PubMed Central ID: 

Roh, Y. S., Park, S., Kim, J. W., Lim, C. W., Seki, E., Kim, B. (2013) Toll-like receptor 7-mediated Type I Interferon signaling prevents cholestasis- and hepatotoxin-induced liver fibrosis. Hepatology. 10.1002/hep.26981.

PubMedID: 24375615
PubMed Central ID: 

Yueh, M. F., Taniguchi, K., Chen, S., Evans, R. M., Hammock, B. D., Karin, M., Tukey, R. H. (2014) The commonly used antimicrobial additive triclosan is a liver tumor promoter. Proc Natl Acad Sci USA. 111(48), 17200-5.

PubMedID: 25404284
PubMed Central ID: 

Mitchell, K. K., Sandoval, S., Cortes-Mateos, M. J., Alfaro, J. G., Kummel, A. C., Trogler, W. C. (2014)  Self-assembled Targeting of Cancer Cells by Iron(III)-doped, Silica Nanoparticles. J Mater Chem B Mater Biol Med. 2(45), 8017-8025.

PubMedID: 25364507

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