SBRP - Superfund Basic Research Program

Project Overview

Project1 – Karin: 1. Maeda S, Kamata H, Luo J-L, Leffert H, Karin M. IKKβ Couples Hepatocyte Cell Death to Cytokine- driven Compensatory Proliferation that Promotes Chemical Hepatocarcinogenesis. Cell 121: 977-990, 2005. ( PDF ); 2. Karin M and Greten FR. NF-kappaB: linking inflammation and immunity to cancer development and progression. Nat Rev Immunol 5(10): 749-59, 2005. ( PDF ); 3. Chang L, Kamata H, Solinas G, Luo JL, Maeda S, Venuprasad K, Liu YC, Karin M. The E3 Ubiquitin Ligase Itch Couples JNK Activation to TNFα-induced Cell Death by Inducing c-FLIPL Turnover. Cell, 2006. In press. ( PDF )

Project 2 – Russell: 4. Martín V, Rodríguez-Gabriel MA, McDonald WH, Watt S, Yates 3rd JR, Bähler J, Russell P. Cip1 and Cip2 are novel RNA-Recognition-Motif proteins that counteract Csx1 function during oxidative stress. Mol. Biol. Cell, 2006. In Press. ( PDF ); 5. Rodriguez-Gabriel MA, Russell P. Distinct signaling pathways respond to arsenite and reactive oxygen species in Schizosaccharomyces pombe. Eukaryotic Cell 4: 1396-1402, 2005. ( PDF )

Project 4 – Tukey: 6. Chen S, Operana T, Bonzo J, Nguyen N, Tukey RH. Erk kinase inhibition stabilizes the aryl hydrocarbon receptor. J. Biol. Chem. 280: 4350-4359, 2005. ( PDF ); 7. Machemer DEW and Tukey RH. The role of protein kinase C in regulation of TCDD-mediated CYP1A1 gene expression. Toxicological Sciences 87: 27-37, 2005. ( PDF ); 8. Bonzo JA, Chen S, Galijatovic A, Tukey RH. Arsenite inihibition of CYP1A1 induction by TCDD is independent of cell cycle arrest. Mol. Pharm. 67: 1247-1256, 2005. ( PDF ); 9. Chen S, Beaton D, Nguyen N, Senekeo-Effenberger K, Brace-Sinnokrak E, Argikar U, Remmel RP, Trottier J, Barbier O, Ritter J, Tukey RH. Tissue-specific, inducible, and hormonal control of the human UDP-glucuronosyltranserase-1 (UGT1) locus. J. Biol. Chem. 280: 37547-37557, 2005. ( PDF )

Project 6 – Taylor: 10. Comoletti D, De Jaco A, Jennings LL, Flynn RE, Gaietta G, Tsigelny I, Ellisman MH, Taylor P. The Arg451 Cys-Neuroligin-3 Mutation Associated with Autism reveals a Defect in Protein Processing. J. Neuro 24 (20): 4889-4893, 2004. ( PDF ); 11. De Jaco A, Comoletti D, Kovarik Z, Gaietta G, Radic Z, Lockridge O, Ellisman MH, Taylor, P. A Mutation Linked With Autism Reveals A Common Mechanism of Endoplasmic Reticulum Retention For the α,β-Hydrolase-Fold Protein Family. Submitted for publication. ( PDF )

Project 7 – Schroeder: 12. Gong JM, Waner DA, Horie T, Li SL, Horie R, Abid KB, Schroeder JI. Microarray-based rapid cloning of an ion accumulation deletion mutant in Arabidopsis thaliana. Proc. Natl. Acad. Sci (USA) 101: 15404-15409, 2004. ( PDF ); 13. Li Y, Dhankher OP, Carreira L, Lee D, Chen A, Schroeder JI, Balish RS, Meagher RB. Overexpression of phytochelatin synthase in Arabidopsis leads to enhanced arsenic tolerance and cadmium hypersensitivity. Plant Cell Physiol. 45: 1787-1797, 2004. ( PDF ); 14. Mori I and Schroeder JI. Reactive Oxygen Species Activation of Plant Ca2+ Channels: A Signaling Mechanism in Polar Growth, Hormone Transduction, Stress Signaling, and Hypothetically Mechano-transduction. Plant Physiology 135: 702-708, 2004. (from in press). ( PDF ); 15. Sunarpi, Horie T, Motoda J, Kubo M, Yang H, Yoda K, Horie R, Chan W, Leung H-Y, Hattori K, Konomi M, Osumi M, Yamagami M, *Schroeder JI, *Uozumi N. (* corresponding authors) Enhanced salt tolerance mediated by AtHKT1 transporter-induced Na+ unloading from xylem parenchyma cells. Pl. Journal 44: 928-938, 2005. ( PDF ); 16. Wycisk K, Kim EJ, Schroeder JI, Kramer U. Enhancing the First Enzymatic Step in Histidine Biosynthesis Pathway Increases the Free Histidine Pool and Nickel Tolerance in Arabidosis Thaliana. FEBS Letters 578: 128-134 (2004). ( PDF )

Project 8 – TEBO: 17. Bencheikh-Latmani R, Williams SM, Haucke L, Criddle CS, Wu L, Zhou J, Tebo BM. Global transcriptional profiling of Shewanella oneidensis MR-1 during Cr(VI) and U(VI) reduction. Applied and Environmental Microbiology 71: 7453-7460, 2005. ( PDF ); 18. Tebo BM, Johnson HA, McCarthy JK, Templeton AS. Geomicrobiology of manganese(II) oxidation. Trends in Microbiology 13: 421-428, 2005. ( PDF ); 19. Murray KJ, Mozafarzadeh ML, Tebo BM. Cr (III) Oxidation and Cr Toxicity in Cultures of the Managanese (II)-Oxidizing Pseudomonas putida Strain GB-1. Geomicrobiology Journal 22: 151-159, 2005. ( PDF )

Research Translation Core: 22. Pezzoli, K. (2005). Building a Global Planning Grid for Progressive Planning Research, Education and Civic-Engagement. GPEIG Voice: Newsletter of the Global Planning Educators Interest Group, University of California, San Diego/ Superfund Basic Research Program, Research Translation Core: 8- 9, 15. ( PDF ); 23. Pezzoli, K. (forthcoming, Summer 2006). Global networks in planning education and practice. American Planning Association (APA) InfoTEXT, APA Information Technology Division, 4 pages. ( PDF ); 24. Pezzoli, K. (in press). Cross-Border Regionalism and Sustainability: Contributions of Critical Regional Ecology. In Equity and Sustainable Development: Regional Reflections from the U.S.-Mexico Border. In J. Clough-Riquelme and N. Bringas Rábago (eds.). La Jolla, CA, Center for U.S.-Mexican Studies, University of California, San Diego.

Community Outreach Core CORE: 25. Pezzoli, K., R. Marciano, et al. (2005). Developing Tools for Watershed-based Analysis in Support of City-Region Planning. Proceedings of the Twenty-fifth Annual ESRI International Users Conference. San Diego, CA, ESRI. ( PDF )