Superfund Publications

Search publications on site
PubMed Central ID: 

Brayman, M. J., Pepa, P. A., Berdy, S. E., Mellon, P. L. (2012) Androgen receptor repression of GnRH gene transcription. Mol. Endocrinol. 26(1), 2-13.

PubMedID: 22074952
PubMed Central ID: 

Budanov, A. V., Lee, J. H., Karin, M. (2010) Stressin' Sestrins take an aging fight. E. M. B. O. Mol. Med. 2(10), 388-400.

PubMedID: 20878915
PubMed Central ID: 

Lee, J. H., Bodmer, R., Bier, E., Karin, M. (2010) Sestrins at the crossroad between stress and aging. Aging (Albany NY). 2(6), 369-74.

PubMedID: 20606249
PubMed Central ID: 

He, G., Yu, G. Y., Temkin, V., Ogata, H., Kuntzen, C., Sakurai, T., Sieghart, W., Peck-Radosavlijevic, M., Leffert, H. L., Karin, M. (2010) Hepatocyte IKKB/NF-KB inhibits tumor promotion and progression by preventing oxidative stress driven STAT3 activation. Cancer Cell. 17(3), 286-297.

PubMedID: 20227042
PubMed Central ID: 

Yueh, M. F., Chen, S., Nguyen, N., Tukey, R. H. (2014) Developmental onset of bilirubin-induced neurotoxicity involves Toll-like receptor 2-dependent signaling in humanized UDP-glucuronosyltransferase1 mice. J. Biol. Chem. 289(8), 4699-709.

PubMedID: 24403077
PubMed Central ID: 

Munemasa, S., Hauser, F., Park, J., Waadt, R., Brandt, B., Schroeder, J. I. (2015) Mechanisms of abscisic acid-mediated control of stomatal aperture. Curr Opin Plant Biol. 28, 154-162.

PubMedID: 26599955
PubMed Central ID: 

Hah, N., Benner, C., Chong, L. W., Yu, R. T., Downes, M., Evans, R. M. (2015) Inflammation-sensitive super enhancers form domains of coordinately regulated enhancer RNAs. Proc Natl Acad Sci U S A. 112(3). E297-302.

PubMedID: 25564661
PubMed Central ID: 
Roybal, L. L., Hambarchyan, A., Meadows, J. D., Barakat, N. H., Pepa, P. A., Breen, K. M., Mellon, P. L., Coss, D. (2014)  Roles of binding elements, FOXL2 domains, and interactions with cJUN and SMADs in regulation of FSHβ. Mol Endocrinol. 28(10), 1640-55.

PubMedID: 25105693
PubMed Central ID: 
Mendoza-Cózatl, D. G., Xie, Q., Akmakjian, G. Z., Jobe, T. O., Patel, A., Stacey, M. G., Song, L., Demoin, D. W., Jurisson, S. S., Stacey, G., Schroeder, J. I. (2014) OPT3 is a component of the iron-signaling network between leaves and roots and misregulation of OPT3 leads to an over-accumulation of cadmium in seeds. Mol Plant. 7(9), 1455-69.
PubMedID: 24880337
PubMed Central ID: 

Kudoh, K., Uchinami, H., Yoshioka, M., Seki, E., Yamamoto, Y. (2013) Nrf2 Activation Protects the Liver From Ischemia/Reperfusion Injury in Mice. Ann Surg. 260(1),118-27.

PubMedID: 24368646
PubMed Central ID: 

Roh, Y. S., Song, J., Seki, E. (2014) TAK1 regulates hepatic cell survival and carcinogenesis. J. Gastroenterol. 49(2),185-94.

PubMedID: 24443058
PubMed Central ID: 

Yang, L., Roh, Y. S., Song, J., Zhang, B., Liu, C., Loomba, R., Seki, E. (2014) Transforming growth factor beta signaling in hepatocytes participates in steatohepatitis through regulation of cell death and lipid metabolism in mice. Hepatology. 59(2), 483-95.

PubMedID: 23996730
PubMed Central ID: 

Breen, K. M., Mellon, P. L. (2014) Influence of stress-induced intermediates on gonadotropin gene expression in gonadotrope cells. Mol. Cell. Endocrinol. 385(1-2), 71-7.

PubMedID: 24012628
PubMed Central ID: 

Yang, L., Inokuchi, S., Roh, Y. S., Song, J., Loomba, R., Park, E. J., Seki, E. (2013) Transforming growth factor-β signaling in hepatocytes promotes hepatic fibrosis and carcinogenesis in mice with hepatocyte-specific deletion of TAK1. Gastroenterology. 144(5), 1042-1054.

PubMedID: 23391818
PubMed Central ID: 

Guo, L., Ghassemian, M., Komives, E. A., Russell, P. (2012) Cadmium-induced proteome remodeling regulated by Spc1/Sty1 and Zip1 in fission yeast. Toxicol Sci. 129(1), 200-12.

PubMedID: 22610605
PubMed Central ID: 

Lee, J. H., Budanov, A. V., Talukdar, S., Park, E. J., Park, H. L., Park, H. W., Bandyopadhyay, G., Li, N., Aghajan, M., Jang, I., Wolfe, A. M., Perkins, G. A., Ellisman, M. H., Bier, E., Scadeng, M., Foretz, M., Viollet, B., Olefsky, J., Karin, M. (2012) Maintenance of metabolic homeostasis by Sestrin2 and Sestrin3. Cell. Metab. 16(3), 311-21.

PubMedID: 22958918
PubMed Central ID: 

Pamenter, M. E., Perkins, G. A., Gu, X. Q., Ellisman, M. H., Haddad, G. G. (2013) DIDS (4,4-diisothiocyanatostilbenedisulphonic acid) induces apoptotic cell death in a hippocampal neuronal cell line and is not neuroprotective against ischemic stress. PLoS One. 10.1371/journal.pone.0060804.

PubMedID: 23577164
PubMed Central ID: 

Pohaku Mitchell, K. K., Liberman, A., Kummel, A. C., Trogler, W. C. (2012) Iron(III)-doped, silica nanoshells: a biodegradable form of silica. J Am Chem Soc. 134(34), 13997-4003.

PubMedID: 22871140
PubMed Central ID: 

Fujiwara, R., Chen, S., Karin, M., Tukey, R. H. (2012) Reduced expression of UGT1A1 in intestines of humanized UGT1 mice via inactivation of NF-κB leads to hyperbilirubinemia. Gastroenterology. 142(1), 109-118.

PubMedID: 21983082
PubMed Central ID: 

Rodríguez-Gabriel, M. A., Russell, P. (2008) Control of mRNA stability by SAPKs. Top Curr Genet. 20, 159-170.

PubMedID: 21738496
PubMed Central ID: 

Larder, R., Clark, D. D., Miller, N. L., Mellon, P. L. (2011) Hypothalamic dysregulation and infertility in mice lacking the homeodomain protein Six6. J. Neurosci. 31(2), 426-38.

PubMedID: 21228153
PubMed Central ID: 

Suhr, S. T., Chang, E. A., Tjong, J., Alcasid, N., Perkins, G. A., Goissis, M. D., Ellisman, M. H., Perez, G. I., Cibelli, J. B. (2010) Mitochondrial rejuvenation after induced pluripotency. PLoS One. doi: 10.1371/journal.pone.0014095.

PubMedID: 21124794
PubMed Central ID: 

He, L., Perkins, G. A., Poblenz, A. T., Harris, J. B., Hung, M., Ellisman, M. H., Fox, D. A., (2003) Bcl-xL overexpression blocks bax-mediated mitochondrial contact site formation and apoptosis in rod photoreceptors of lead-exposed mice. Proc Natl Acad Sci USA. 100(3),1022-7

PubMedID: 12540825
PubMed Central ID: 

Miller, N. L., Wevrick, R., Mellon, P. L. (2009)  Necdin, a Prader-Willi syndrome candidate gene, regulates gonadotropin-releasing hormone neurons during development. Hum. Mol. Genet. 18(2), 248-60.

PubMedID: 18930956
PubMed Central ID: 

Yamaguchi, R., Lartigue, L., Perkins, G., Scott, R. T., Dixit, A., Kushnareva, Y., Kuwana, T., Ellisman, M. H., (2008) Newmeyer DD.Opa1-mediated cristae opening is Bax/Bak and BH3 dependent, required for apoptosis, and independent of Bak oligomerization. Mol Cell. 31(4), 557-69.

PubMedID: 18691924
PubMed Central ID: 

Gong, J. M., Lee, D. A., Schroeder, J. I. (2003) Long-distance root-to-shoot transport of phytochelatins and cadmium in Arabidopsis. Proc Natl Acad Sci USA. 100(17), 10118-23. doi: 10.1073/pnas.1734072100.

PubMedID: 12909714
PubMed Central ID: 

Rodríguez-Gabriel, M. A., Watt, S., Bähler, J., Russell, P. (2006) Upf1, an RNA helicase required for nonsense-mediated mRNA decay, modulates the transcriptional response to oxidative stress in fission yeast. Mol Cell Biol. 26, 6347-6356.

PubMedID: 16914721
PubMed Central ID: 

Sánchez, A., Roguev, A., Krogan, N.J., Russell, P. (2015) Genetic Interaction Landscape Reveals Critical Requirements for Schizosaccharomyces pombe Brc1 in DNA Damage Response Mutants. G3 (Bethesda). 5(5), 953-62.

PubMedID: 25795664
PubMed Central ID: 

Wang, L., Limbo, O., Fei, J., Chen, L., Kim, B., Luo, J., Chong, J., Conaway, R. C., Conaway, J. W., Ranish, J. A., Kadonaga, J. T., Russell, P., Wang, D. (2014) Regulation of the Rhp26ERCC6/CSB chromatin remodeler by a novel conserved leucine latch motif.  Proc Natl Acad Sci U S A111(52), 18566-71.

PubMedID: 25512493
PubMed Central ID: 

Moles, A., Murphy, L., Wilson, C. L., Chakraborty, J. B., Fox, C., Park, E. J., Mann, J., Oakley, F., Howarth, R., Brain, J., Masson, S., Karin, M., Seki, E., Mann, D. A. (2014) A TLR2/S100A9/CXCL-2 signaling network is necessary for neutrophil recruitment in acute and chronic liver injury in the mouse. J Hepatol. 60(4), 782-91.

PubMedID: 24333183
PubMed Central ID: 

Witham, E. A., Meadows, J. D., Hoffmann, H. M., Shojaei, S., Coss, D., Kauffman, A. S., Mellon, P. L. (2013)  Kisspeptin regulates gonadotropin genes via immediate early gene induction in pituitary gonadotropes. Mol. Endocrinol27(8), 1283-94.

PubMedID: 23770611
PubMed Central ID: 

Roh, Y. S., Seki, E. (2013) Toll-like receptors in alcoholic liver disease, non-alcoholic steatohepatitis and carcinogenesis. J Gastroenterol Hepatol. 1, 38-42.

PubMedID: 23855294
PubMed Central ID: 

Xie, H., Cherrington, B. D., Meadows, J. D., Witham, E. A., Mellon, P. L. (2013) Msx1 homeodomain protein represses the αGSU and GnRH receptor genes during gonadotrope development. Mol. Endocrinol. 27(3), 422-36.

PubMedID: 23371388
PubMed Central ID: 

Perkins, G. A., Scott, R., Perez, A., Ellisman, M. H., Johnson, J. E., Fox, D. A.. (2012) Bcl-xL-mediated remodeling of rod and cone synaptic mitochondria after postnatal lead exposure: electron microscopy, tomography and oxygen consumption. Mol Vis. 18, 3029-48

PubMedID: 23288995
PubMed Central ID: 

Falivelli, G., De Jaco, A., Favaloro, F. L., Kim, H., Wilson, J., Dubi, N., Ellisman, M. H., Abrahams, B. S., Taylor, P., Comoletti, D. (2012) Inherited genetic variants in autism-related CNTNAP2 show perturbed trafficking and ATF6 activation. Hum Mol Genet. 21(21), 4761-73.

PubMedID: 22872700
PubMed Central ID: 

Brayman, M. J., Pepa, P. A., Mellon, P. L. (2012) Androgen receptor repression of gonadotropin-releasing hormone gene transcription via enhancer 1. Mol. Cell. Endocrinol. 363(1-2), 92-9.

PubMedID: 22877652
PubMed Central ID: 

Witham, E. A., Meadows, J. D., Shojaei, S., Kauffman, A. S., Mellon, P. L. (2012) Prenatal exposure to low levels of androgen accelerates female puberty onset and reproductive senescence in mice. Endocrinology. 153(9), 4522-32.

PubMedID: 22778229
PubMed Central ID: 

Cherrington, B. D., Bailey, J. S., Diaz, A. L., Mellon, P. L. (2008) NeuroD1 and Mash1 temporally regulate GnRH receptor gene expression in immortalized mouse gonadotrope cells. Mol Cell Endocrinol. 295(1-2),106-14.

PubMedID: 18760324

Greten, F. R., Eckmann, L., Greten, T. F., Park, J. M., Li, Z. W., Egan, L. J., Kagnoff, M. F., Karin, M. (2004) IKKbeta links inflammation and tumorigenesis in a mouse model of colitis-associated cancer. Cell. 118(3), 285-96. doi: 10.1016/j.cell.2004.07.013

PubMedID: 15294155

Wycisk, K., Kim, E. J., Schroeder, J. I., Kramer, U. (2004) Enhancing the First Enzymatic Step in Histidine Biosynthesis Pathway Increases the Free Histidine Pool and Nickel Tolerance in Arabidosis Thaliana. FEBS Letters. 578, 128-134. doi: 10.1016/j.febslet.2004.10.086

PubMedID: 15581629

Yueh, M. F., Huang, Y. H., Hiller, A., Chen, S., Nguyen, N., Tukey, R. H. (2003) Involvement of the xenobiotic response element (XRE) in Ah receptor-mediated induction of human UDP-glucuronosyltransferase 1A1. J Biol Chem. 278(17), 15001-6. doi: 10.1074/jbc.M300645200.

PubMedID: 12566446

Petersen J., Russell P. (2016) Erratum: Growth and the Environment of Schizosaccharomyces pombe. Cold Spring Harb Protoc. 2016(3):pdb.top079764. doi: 10.1101/pdb.top079764. Erratum in: Cold Spring Harb Protoc. 2016;2016(4):pdb.err093682. Cold Spring Harb Protoc. 2016;2016(7):pdb.corr095232.

PubMedID: 26933253

Bonizzi, G., Karin, M. (2004) The two NF-kappaB activation pathways and their role in innate and adaptive immunity. Trends Immunol. 25(6), 280-8. doi: 10.1016/

PubMedID: 15145317

Seki, E., Schwabe, R. F. (2014) Hepatic Inflammation and Fibrosis: Functional Links and Key Pathways. Hepatology. doi: 10.1002/hep.27332.

PubMedID: 25066777

Nguyen, N., Bonzo, J.A., Chen, S., Chouinard, S., Kelner, M., Hardiman, G., Belanger, A., and Tukey, R.H. (2008) Disruption of the Ugt1 locus in mice resembles human Crigler-Najjar type I disease. J. Biol. Chem. 283. 7901-7911

PubMedID: 18180294

Galijatovic, A., Beaton, D., Nguyen, N., Chen, S., Bonzo, J., Johnson, R., Maeda, S., Karin, M., Guengerich, F. P., Tukey, R. H. (2004) The human CYP1A1 gene is regulated in a developmental and tissue-specific fashion in transgenic mice. J Biol Chem. 279(23), 23969-76. doi: 10.1074/jbc.M400973200

PubMedID: 15037607

Yueh, M.F., and Tukey, R.H. (2007) Nrf2-Keap1 signaling pathway regulates human UGT1A1 expression in vitro and in transgenic UGT1 mice. J. Biol. Chem. 282: 8749-8758

PubMedID: 17259171

Suh, J.M., Jonker, J. W., Ahmadian, M., Goetz, R., Lackey, D., Osborn, O., Huang, Z., Liu, W., Yoshihara, E., van Dijk, T. H., Havinga, R., Fan, W., Yin, Y. Q., Yu, R. T., Liddle, C., Atkins, A. R., Olefsky, J. M., Mohammadi, M., Downes, M., Evans, R. M. (2014) Corrigendum: Endocrinization of FGF1 produces a neomorphic and potent insulin sensitizer. Nature. 520(7547):388. doi: 10.1038/nature14304.

PubMedID: 25739500

Maeda, S., Chang, L., Li, Z. W., Luo, J. L., Leffert, H., Karin, M. (2003) IKKbeta is required for prevention of apoptosis mediated by cell-bound but not by circulating TNFalpha. Immunity. 19(5), 725-37. doi: 10.1016/S1074-7613(03)00301-7.

PubMedID: 14614859

Machemer D. E. W., and Tukey R. H. (2005) The role of protein kinase C in regulation of TCDD-mediated CYP1A1 gene expression. Toxicol Sci. 87(1):27-37. doi: 10.1093/toxsci/kfi220.

PubMedID: 15947024