Superfund Publications

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The TM6SF2 variants, novel genetic predictors for nonalcoholic steatohepatitis. (2015) Roh, Y. S., Loomba, R., Seki, E. Gastroenterology. 148(1), 252-4.

PubMedID: 25451657

Bonzo, J. A., Belanger, A., and Tukey, R. H. (2007) The role of chrysin and the Ah receptor in induction of the human UGT1A1 gene in vitro and in transgenic UGT1 mice. Hepatology. 45, 349-360.

PubMedID: 17256720

Platten, J. D., Cotsaftis, O., Berthomieu, P., Bohnert, H., Davenport, R. J., Fairbairn, D. J., Horie, T., Leigh, R.A., Lin, H. X., Luan, S., Maser, P., Pantoja, O., Rodriguez-Navarro, A., Schachtman, D. P., Schroeder, J. I., Sentenac, H., Uozumi, N., Very AA, Zhu JK, Dennis ES, Tester M. (2006) Nomenclature for HKT transporters, key determinants of plant salinity tolerance. Trends Plant Sci. 11, 372-374. doi: 10.1016/j.tplants.2006.06.001.

PubMedID: 16809061

Shi, J., Koeppe, J. R., Komives, E. A., Taylor, P., (2006) Ligand-induced conformational changes in the acetylcholine-binding protein analyzed by hydrogen-deuterium exchange mass spectrometry. J Biol Chem. 281(17), 12170-7.

PubMedID: 16484218

Operaña, T. N., Nguyen, N., Chen, S., Beaton, D. and Tukey, R. H. (2007) Human CYP1A1GFP expression in transgenic mice serves as a biomarker for environmental toxicant exposure. Toxicol Sci. 95(1):98-107. doi: 10.1093/toxsci/kfl144.

PubMedID: 17065433

Schroeder, J. I., Nambara, E. (2006) A quick release mechanism for abscisic acid. Cell. 126, 1023-1025. doi: 10.1016/j.cell.2006.09.001.

PubMedID: 16990126
PubMedID: 15630080

Jennings, L. L., Malecki, M., Komives, E. A., Taylor, P., (2003) Direct analysis of the kinetic profiles of organophosphate-acetylcholinesterase adducts by MALDI-TOF mass spectrometry. Biochemistry. 42(37), 11083-91.

PubMedID: 12974645

Machemer, D. E. W., and Tukey, R. H. (2005) The role of protein kinase C in regulation of TCDD-mediated CYP1A1 gene expression. Toxicological Sciences. 87, 27-37.

PubMedID: 15947024

Schroeder, J. I., Kuhn, J. M. (2006) Plant biology abscisic acid in bloom. Nature. 439, 277-278. doi: 10.1038/439277a

PubMedID: 16421556

Ghassemian, M., Waner, D., Tchieu, J., Gribskov, M., Schroeder, J. I. (2001) An integrated Arabidopsis annotation database for Affymetrix Genechip data analysis, and tools for regulatory motif searches. Trends Plant Sci. 6(10), 448-9. doi: 10.1016/S1360-1385(01)02092-1.

PubMedID: 11590042

Dooley, C. T., Dore, T. M., Hanson, G. T., Jackson, W. C., Remington, S. J., Tsien, R. Y., (2004) Imaging dynamic redox changes in mammalian cells with green fluorescent protein indicators. J. Biol. Chem. 279(21), 22284-93.

PubMedID: 14985369

Chen, S., Operana, T., Bonzo, J., Nguyen, N., Tukey R. H. (2005) Erk kinase inhibition stabilizes the aryl hydrocarbon receptor. J Biol Chem. 280(6):4350-9. doi: 10.1074/jbc.M411554200.

PubMedID: 15572374

Sunarpi, Horie, T., Motoda, J., Kubo, M., Yang, H., Yoda, K., Horie, R., Chan, W., Leung, H. Y., Hattori, K., Konomi, M., Osumi, M., Yamagami, M., *Schroeder, J. I., *Uozumi, N. (* corresponding authors) (2005)  Enhanced salt tolerance mediated by AtHKT1 transporter-induced Na+ unloading from xylem parenchyma cells. Pl Journal. 44, 928-938. doi: 10.1111/j.1365-313X.2005.02595.x

PubMedID: 16359386

Clemens, S., Schroeder, J. I., Degenkolb, T. (2001) Caenorhabditis elegans expresses a functional phytochelatin synthase. Eur J Biochem. 268(13), 3640-3. doi: 10.1046/j.1432-1327.2001.02293.x.

 
PubMedID: 11432729

Li, Y., Dhankher, O. P., Carreira, L., Lee, D., Chen, A., Schroeder, J. I., Balish, R. S., Meagher, R. B. (2004) Overexpression of phytochelatin synthase in Arabidopsis leads to enhanced arsenic tolerance and cadmium hypersensitivity. Plant Cell Physiol. 45, 1787-1797. doi: 10.1093/pcp/pch202.

PubMedID: 15653797

Wycisk, K., Kim, E. J., Schroeder, J. I., Kramer, U. (2004) Enhancing the First Enzymatic Step in Histidine Biosynthesis Pathway Increases the Free Histidine Pool and Nickel Tolerance in Arabidosis Thaliana. FEBS Letters. 578, 128-134. doi: 10.1016/j.febslet.2004.10.086

PubMedID: 15581629

Yueh, M. F., Huang, Y. H., Hiller, A., Chen, S., Nguyen, N., Tukey, R. H. (2003) Involvement of the xenobiotic response element (XRE) in Ah receptor-mediated induction of human UDP-glucuronosyltransferase 1A1. J Biol Chem. 278(17), 15001-6. doi: 10.1074/jbc.M300645200.

PubMedID: 12566446

Greten, F. R., Eckmann, L., Greten, T. F., Park, J. M., Li, Z. W., Egan, L. J., Kagnoff, M. F., Karin, M. (2004) IKKbeta links inflammation and tumorigenesis in a mouse model of colitis-associated cancer. Cell. 118(3), 285-96. doi: 10.1016/j.cell.2004.07.013

PubMedID: 15294155

Seki, E., Schwabe, R. F. (2014) Hepatic Inflammation and Fibrosis: Functional Links and Key Pathways. Hepatology. doi: 10.1002/hep.27332.

PubMedID: 25066777

Nguyen, N., Bonzo, J.A., Chen, S., Chouinard, S., Kelner, M., Hardiman, G., Belanger, A., and Tukey, R.H. (2008) Disruption of the Ugt1 locus in mice resembles human Crigler-Najjar type I disease. J. Biol. Chem. 283. 7901-7911

PubMedID: 18180294

Seki, E. (2015) HEDGEHOG signal in Hepatocytes mediates Macrophage Recruitment: A New Mechanism and Potential Therapeutic Target for Fatty Liver Disease. Hepatology.  doi: 10.1002/hep.28381.

PubMedID: 26638191

Hartmann P., Hochrath K., Horvath A., Chen P., Seebauer C.T., Llorente C., Wang L., Alnouti Y., Fouts D.E., Stärkel P., Loomba R., Coulter S., Liddle C., Yu R.T., Ling L., Rossi S.J., DePaoli A.M., Downes M., Evans R.M., Brenner D.A., Schnabl B. (2017) Modulation of the intestinal bile acid-FXR-FGF15 axis improves alcoholic liver disease in mice. Hepatology. doi: 10.1002/hep.29676.

PubMedID: 29159825

Bonizzi, G., Karin, M. (2004) The two NF-kappaB activation pathways and their role in innate and adaptive immunity. Trends Immunol. 25(6), 280-8. doi: 10.1016/j.it.2004.03.008

PubMedID: 15145317

Galijatovic, A., Beaton, D., Nguyen, N., Chen, S., Bonzo, J., Johnson, R., Maeda, S., Karin, M., Guengerich, F. P., Tukey, R. H. (2004) The human CYP1A1 gene is regulated in a developmental and tissue-specific fashion in transgenic mice. J Biol Chem. 279(23), 23969-76. doi: 10.1074/jbc.M400973200

PubMedID: 15037607

Yueh, M.F., and Tukey, R.H. (2007) Nrf2-Keap1 signaling pathway regulates human UGT1A1 expression in vitro and in transgenic UGT1 mice. J. Biol. Chem. 282: 8749-8758

PubMedID: 17259171

Suh, J.M., Jonker, J. W., Ahmadian, M., Goetz, R., Lackey, D., Osborn, O., Huang, Z., Liu, W., Yoshihara, E., van Dijk, T. H., Havinga, R., Fan, W., Yin, Y. Q., Yu, R. T., Liddle, C., Atkins, A. R., Olefsky, J. M., Mohammadi, M., Downes, M., Evans, R. M. (2014) Corrigendum: Endocrinization of FGF1 produces a neomorphic and potent insulin sensitizer. Nature. 520(7547):388. doi: 10.1038/nature14304.

PubMedID: 25739500

Maeda, S., Chang, L., Li, Z. W., Luo, J. L., Leffert, H., Karin, M. (2003) IKKbeta is required for prevention of apoptosis mediated by cell-bound but not by circulating TNFalpha. Immunity. 19(5), 725-37. doi: 10.1016/S1074-7613(03)00301-7.

PubMedID: 14614859

Machemer D. E. W., and Tukey R. H. (2005) The role of protein kinase C in regulation of TCDD-mediated CYP1A1 gene expression. Toxicol Sci. 87(1):27-37. doi: 10.1093/toxsci/kfi220.

PubMedID: 15947024

Bonzo, J. A., Belanger, A., and Tukey, R. H. (2007) The role of chrysin and the Ah receptor in induction of the human UGT1A1 gene in vitro and in transgenic UGT1 mice. Hepatology. 45, 349-360.

PubMedID: 17256720
Liang, S., Zhong, Z., Seki, E. (2014)  Novel fate-tracing strategies show that hepatic stellate cells mediate fibrosis in vivo. astroenterology. 146(7), 1823-5. 
PubMedID: 24768331

Li, Z. W., Omori, S. A., Labuda, T., Karin, M., Rickert, R. C. (2003) IKK beta is required for peripheral B cell survival and proliferation. J Immunol. 170(9), 4630-7. doi: 10.4049/jimmunol.170.9.4630.

PubMedID: 12707341

Chen, S., Beaton, D., Nguyen, N., Senekeo-Effenberger, K., Brace-Sinnokrak, E., Argikar, U., Remmel, R. P., Trottier, J., Barbier, O., Ritter, J., Tukey, R. H. (2005) Tissue-specific, inducible, and hormonal control of the human UDP-glucuronosyltranserase-1 (UGT1) locus. J Biol Chem. 280(45):37547-57. doi: 10.1074/jbc.M506683200.

PubMedID: 16155002

Senekeo-Effenberger, K., Chen, S., Yueh, M-F., Erace-Sinnokrak, E., Bonzo, J.A., Argikar, U., Kaeding, J., Trottier, T., Remmel, R.P., Ritter, J.K., Barbier, O., and Tukey, R.H. (2007) Expression of the human UGT1 locus in transgenic mice by 4-chloro-6-(2,3-xylidino)-2-pyrimidinylthioacetic acid (WY-14643) and implications on drug metabolism through peroxisome proliferator-activated receptor alpha activation. Drug Met. Disp. 35, 419-427.

PubMedID: 17151188

Chen, S., Nguyen, N., Tamura, K., Karin, M., Tukey, R. H. (2003) The role of the Ah receptor and p38 in benzo[a]pyrene-7,8-dihydrodiol and benzo[a]pyrene-7,8-dihydrodiol-9,10-epoxide-induced apoptosis. J Biol Chem. 278(21), 19526-33. doi: 10.1074/jbc.M300780200.

PubMedID: 12637498

Bonzo, J. A., Chen, S., Galijatovic, A., Tukey, R. H. (2005) Arsenite inihibition of CYP1A1 induction by TCDD is independent of cell cycle arrest. Mol Pharmacol. 67(4):1247-56. doi: 10.1124/mol.104.006130.

PubMedID: 15630080

Chen, S., Beaton, D., Nguyen, N., Senekeo-Effenberger, K., Brace-Sinnokrak, E., Argikar, U., Remmel, R. P., Trottier, J., Barbier, O., Ritter, J., Tukey, R. H. (2005) Tissue-specific, inducible, and hormonal control of the human UDP-glucuronosyltranserase-1 (UGT1) locus. J. Biol. Chem. 280, 37547-37557.

PubMedID: 16155002

 Abe, Y., Uchinami, H., Kudoh, K., Nakagawa, Y., Ise, N., Watanabe, G., Sato, T., Seki, E., Yamamoto, Y. (2012)  Liver epithelial cells proliferate under hypoxia and protect the liver from ischemic injury via expression of HIF-1 alpha target genes. Surgery. 152(5), 869-78.

PubMedID: 22575885

Park, J. M., Greten, F. R., Li, Z. W., Karin, M. (2002) Macrophage apoptosis by anthrax lethal factor through p38 MAP kinase inhibition. Science. 297(5589), 2048-51. doi: 10.1126/science.1073163

PubMedID: 12202685

Yueh, M. F., and Tukey, R. H. (2007) Nrf2-Keap1 signaling pathway regulates human UGT1A1 expression in vitro and in transgenic UGT1 mice. J Biol Chem. 282(12):8749-58. doi: 10.1074/jbc.M610790200.

PubMedID: 17259171

Machemer D. E. W., and Tukey R. H. (2005) The role of protein kinase C in regulation of TCDD-mediated CYP1A1 gene expression. Toxicological Sciences. 87, 27-37.

PubMedID: 15947024

Al-Delaimy, W. K., Larsen, C. W., Pezzoli, K. (2014) Differences in health symptoms among residents living near illegal dump sites in Los Laureles Canyon, Tijuana, Mexico: a cross sectional survey. In.t J. Environ. Res. Public Health. 11(9), 9532-52.

PubMedID: 25226411

Senekeo-Effenberger, K., Chen, S., Yueh, M-F., Erace-Sinnokrak, E., Bonzo, J. A., Argikar, U., Kaeding, J., Trottier, T., Remmel, R. P., Ritter, J. K., Barbier, O., and Tukey, R. H. (2007) Expression of the human UGT1 locus in transgenic mice by 4-chloro-6-(2,3-xylidino)-2-pyrimidinylthioacetic acid (WY-14643) and implications on drug metabolism through peroxisome proliferator-activated receptor alpha activation. Drug Met Disp. 35(3):419-27. doi: 10.1124/dmd.106.013243.

PubMedID: 17151188

Huang, Y. H., Galijatovic, A., Nguyen, N., Geske, D., Beaton, D., Green, J., Green, M., Peters, W. H., Tukey, R. H. (2002) Identification and functional characterization of UDP-glucuronosyltransferases UGT1A8*1, UGT1A8*2 and UGT1A8*3. Pharmacogenetics.12(4), 287-97.

PubMedID: 12042666

Bonzo, J. A., Belanger, A., and Tukey, R. H. (2007) The role of chrysin and the Ah receptor in induction of the human UGT1A1 gene in vitro and in transgenic UGT1 mice. Hepatology. 45(2):349-60. doi: 10.1002/hep.21481.

PubMedID: 17256720

Stephens, S. B., Tolson, K. P., Rouse, M. L., Poling, M. C., Hashimoto-Partyka, M. K., Mellon, P. L., Kauffman, A. S. (2015) Absent Progesterone Signaling in Kisspeptin Neurons Disrupts the LH Surge and Impairs Fertility in Female Mice. Endocrinology. en20151300

PubMedID: 26076042

Germain, P., Chambon, P., Eichele, G., Evans, R. M., Lazar, M. A., Leid, M., De Lera, A. R., Lotan, R., Mangelsdorf, D. J., Gronemeyer, H. (2006) Pharmacol Rev. 58(4), 760-72.

PubMedID: 17132853

Nguyen, N., Bonzo, J. A., Chen, S., Chouinard, S., Kelner, M., Hardiman, G., Belanger, A., and Tukey, R. H. (2008) Disruption of the Ugt1 locus in mice resembles human Crigler-Najjar type I disease. J Biol Chem. 283(12):7901-11. doi: 10.1074/jbc.M709244200.

PubMedID: 18180294

Suh, J. M., Jonker, J. W., Ahmadian, M., Goetz, R., Lackey, D., Osborn, O., Huang, Z., Liu, W., Yoshihara, E., van Dijk, T. H., Havinga, R., Fan, W., Yin, Y. Q., Yu, R. T., Liddle, C., Atkins, A. R., Olefsky, J. M., Mohammadi, M., Downes, M., Evans, R. M. (2015) Corrigendum: Endocrinization of FGF1 produces a neomorphic and potent insulin sensitizer. Nature. 520(7547), 388. doi: 10.1038/nature14304.

PubMedID: 25739500

Lu, B., Bridges, D., Yang, Y., Fisher, K., Cheng, A., Chang, L., Meng, Z., Lin, J., Downes, M., Yu, R. T., Liddle, C., Evans, R. M., Saltiel, A. R. (2014) Metabolic Crosstalk: molecular links between glycogen and lipid metabolism in obesity. Diabetes.

PubMedID: 24722244

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